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Upside Down Pizza Casserole

USAFireAndRescue's picture
Upside Down Pizza Casserole is an easy pizza casserole recipe that uses biscuits instead of pizza dough! Watch the recipe video below and then give it a try!!
  Ground beef 1 Pound
  Onion 1 Medium, diced
  Garlic powder 1⁄2 Teaspoon
  Pizza sauce 15 Ounce, 1 jar
  Turkey pepperoni 4 Ounce, slice
  Mozarella cheese 4 Ounce, shredded
  Buttermilk biscuits 1 4⁄5 Ounce

1)Preheat oven to 400 degrees and spray a 2 qt baking dish with non-stick cooking spray.
2)In a large skillet over medium heat, brown the ground beef, onion and garlic powder and drain off any excess grease.
3)Add mushrooms, turkey pepperoni slices and pizza sauce and heat through.
4)Pour the mixture into the baking dish.
5)Top with shredded mozzarella cheese and top with biscuit pieces.
6)Bake in the oven for 10 - 15 minutes, or until the biscuits are nicely browned and the casserole is bubbling.

7)Serve hot with your choice of sides and enjoy!

To make sure cutting the biscuits is easier, place the biscuits on a cutting board and roll a pizza cutter on them to cut them into quarters.

Recipe Summary

Difficulty Level: 
Main Dish
Preparation Time: 
30 Minutes
Cook Time: 
20 Minutes
Ready In: 
50 Minutes

Rate It

Your rating: None
Average: 4.1 (4 votes)

Nutrition Rank

Nutrition Facts

Serving size: Complete recipe

Calories 2328 Calories from Fat 1432

% Daily Value*

Total Fat 164 g251.7%

Saturated Fat 62.9 g314.3%

Trans Fat 0 g

Cholesterol 516.9 mg172.3%

Sodium 3312.4 mg138%

Total Carbohydrates 88 g29.3%

Dietary Fiber 13.4 g53.8%

Sugars 21.5 g

Protein 139 g278.7%

Vitamin A 72.1% Vitamin C 106.3%

Calcium 85.2% Iron 78.8%

*Based on a 2000 Calorie diet


veg.foodie's picture
hi amy! nice to see you again! can you suggest a quick fix veggie substitute for the meat....? maybe marinated soy nuggets.. I definitely want something with a bite to it.. :)
USAFireAndRescue's picture
Hi veg foodie! How have you been? I hope all is going great with you and yours! Thank you so much for watching. I'm sorry this recipe isn't a good one for you... it is loaded with a lot of meat. :-( The Boca "meat" crumbles would probably work great in place of the ground beef. You could also load up on veggies with this... black olives and green pepper slices would be awesome. I was going to add those, but I was completely out when we shot this video. I hope you have a beautiful weekend sweetie! Big big hugs to you!!!
veg.foodie's picture
oh..yes! black olives... dats not bad :) N i use boca for burgers too... dats is great idea actually... thanks a lot! I had a lovely weekend :) u have a great week too!! cheers!
USAFireAndRescue's picture
Something else that we added after it was done was pineapple chunks! It was a little like a hawaiian pizza! Yummy! Hope you can give it a try!
Prezi's picture
Hey Amy! This upside down casserole seems to be very inventive recipe; also this seems to be a very easy one to try. However, I would like to go for a chicken substitute for beef; so in that case, will I have to reduce the cooking time? Also what is best accompaniment I can team this Upside Down Pizza Casserole with; do let me knoW!
USAFireAndRescue's picture
Hi Prezi! How have you been? I hope all is great with you and yours! Chicken would work great as well. Just cook the chicken first and then add it to the baking dish. Baking time should not change, as you just want to heat the dish through and cook the biscuits. Bread sticks would go great with this... also a salad. :-) Have a most beautiful day sweetie! Thank you for watching and posting! :-))) Hugs to you!
ifoodiee's picture
Amazing..:-)..a filling dish too..a very unique recipe Amy...loved it...though i would be using chicken too..not that fond of beef:-)...
USAFireAndRescue's picture
Hi ifoodiee! How are you? Thank you so much for watching and commenting. Chicken will work great too! Turkey italian sausage is another great addition! If you like pineapple, adding some chunks after it is done makes it really yummy! There's so many wonderful variations with this. Green Peppers are good too... black olives... even hot peppers! :-) I hope you can make this. Just be careful with those exploding biscuit cans, LOL. I hate opening those things! Big hugs to you and yours!!!
ifoodiee's picture
I just love it when you reply so fast..i get my info when i really really need it and not ages later:-)..thanks a lot are a sweetheart:-)..hugs back to you too..
USAFireAndRescue's picture
Awwww.... you are so sweet ifoodiee! :-) You've made my day! Big, big hugs to you sweetie!
aparna.priya's picture
hey amy, you would be delighted to know that yesterday i tried this upside down pizza was simply great! however, instead of beef, i used tasted amazing. keep posting such delicious and simple ones...:))
USAFireAndRescue's picture
This is wonderful! Thank you so much for posting and letting me know how this recipe turned out for you! Chicken instead of beef is a great substitution! I've never tried it with chicken, so I'm really wanting to make this again and try it! I think I'm out of biscuits though :-( Have a most beautiful day and thank you again for watching and posting! Big hugs to you! :-)
Upside Down Pizza Casserole Recipe Video